Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection.
Identifieur interne : 007147 ( Main/Exploration ); précédent : 007146; suivant : 007148Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection.
Auteurs : R K Shenoy [Inde] ; T K Suma ; V. Kumaraswami ; N. Rahmah ; G. Dhananjayan ; S. Padma ; G. Abhilash ; C. RameshSource :
- Annals of tropical medicine and parasitology [ 0003-4983 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent, Animaux, Brugia malayi (isolement et purification), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (parasitologie), Humains, Immunoglobuline G (sang), Inde (épidémiologie), Mâle, Noeuds lymphatiques (imagerie diagnostique), Scintigraphie, Études transversales.
- MESH :
- diagnostic : Filariose lymphatique.
- imagerie diagnostique : Noeuds lymphatiques.
- isolement et purification : Brugia malayi.
- parasitologie : Filariose lymphatique.
- sang : Immunoglobuline G.
- épidémiologie : Inde.
- Adolescent, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Scintigraphie, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Animals, Brugia malayi (isolation & purification), Child, Child, Preschool, Cross-Sectional Studies, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (parasitology), Female, Humans, Immunoglobulin G (blood), India (epidemiology), Lymph Nodes (diagnostic imaging), Male, Radionuclide Imaging.
- MESH :
- chemical , blood : Immunoglobulin G.
- diagnosis : Elephantiasis, Filarial.
- diagnostic imaging : Lymph Nodes.
- epidemiology : India.
- isolation & purification : Brugia malayi.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Animals, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Radionuclide Imaging.
Abstract
As the more obvious clinical manifestations of the disease are very uncommon in children, lymphatic filariasis has been considered to be primarily a disease of adults. In many recent reports, however, there is evidence indicating not only that filarial infection is commonly acquired in childhood but also that many infected children already have irreversible damage to their lymphatics. The preliminary results of a cross-sectional study on the patterns of Brugia-attributable pathology in 7934 children (aged 3-15 years) who live in an area of India with endemic B. malayi infection confirm these trends. The children were screened for microfilaraemia, evidence of filarial disease, and the presence of antifilarial IgG(4) antibodies. One hundred children who were microfilaraemic but asymptomatic (32), with filarial disease or an history of such disease or microfilaraemia (29) or amicrofilaraemic and asymptomatic but seropositive for antifilarial IgG(4) (39) were investigated further. They were given detailed clinical examinations, their levels of microfilaraemia were evaluated (by counting microfilariae filtered out of blood samples), their lymphatics were explored by Doppler sonography, and their limbs were checked by lymphoscintigraphy. The 'filarial dance sign', which indicates the presence of live adult worms, was detected by sonography in 14 children (apparently the first time this sign has been observed in brugian filariasis). Lymphoscintigraphy revealed dilated lymphatic channels in the limbs of 80 of the children. At the end of the study, each of the 100 hospitalized children was treated with a single combined dose of diethylcarbamazine and albendazole; the aim is to follow-up the treated children every 6 months for 3 years. Even these preliminary results have important implications for filariasis-control programmes and emphasise the need for disability-alleviation efforts among children as well as adults.
DOI: 10.1179/136485907X154548
PubMed: 17362595
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003724
- to stream PubMed, to step Curation: 003724
- to stream PubMed, to step Checkpoint: 003724
- to stream Ncbi, to step Merge: 002618
- to stream Ncbi, to step Curation: 002618
- to stream Ncbi, to step Checkpoint: 002618
- to stream Main, to step Merge: 007275
- to stream Main, to step Curation: 007147
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection.</title><author><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name><affiliation wicri:level="1"><nlm:affiliation>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha - 688 011, Kerala, India. drrkshenoy@gmail.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha - 688 011, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Rahmah, N" sort="Rahmah, N" uniqKey="Rahmah N" first="N" last="Rahmah">N. Rahmah</name></author><author><name sortKey="Dhananjayan, G" sort="Dhananjayan, G" uniqKey="Dhananjayan G" first="G" last="Dhananjayan">G. Dhananjayan</name></author><author><name sortKey="Padma, S" sort="Padma, S" uniqKey="Padma S" first="S" last="Padma">S. Padma</name></author><author><name sortKey="Abhilash, G" sort="Abhilash, G" uniqKey="Abhilash G" first="G" last="Abhilash">G. Abhilash</name></author><author><name sortKey="Ramesh, C" sort="Ramesh, C" uniqKey="Ramesh C" first="C" last="Ramesh">C. Ramesh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17362595</idno><idno type="pmid">17362595</idno><idno type="doi">10.1179/136485907X154548</idno><idno type="wicri:Area/PubMed/Corpus">003724</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003724</idno><idno type="wicri:Area/PubMed/Curation">003724</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003724</idno><idno type="wicri:Area/PubMed/Checkpoint">003724</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003724</idno><idno type="wicri:Area/Ncbi/Merge">002618</idno><idno type="wicri:Area/Ncbi/Curation">002618</idno><idno type="wicri:Area/Ncbi/Checkpoint">002618</idno><idno type="wicri:doubleKey">0003-4983:2007:Shenoy R:preliminary:findings:from</idno><idno type="wicri:Area/Main/Merge">007275</idno><idno type="wicri:Area/Main/Curation">007147</idno><idno type="wicri:Area/Main/Exploration">007147</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection.</title><author><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name><affiliation wicri:level="1"><nlm:affiliation>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha - 688 011, Kerala, India. drrkshenoy@gmail.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha - 688 011, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Rahmah, N" sort="Rahmah, N" uniqKey="Rahmah N" first="N" last="Rahmah">N. Rahmah</name></author><author><name sortKey="Dhananjayan, G" sort="Dhananjayan, G" uniqKey="Dhananjayan G" first="G" last="Dhananjayan">G. Dhananjayan</name></author><author><name sortKey="Padma, S" sort="Padma, S" uniqKey="Padma S" first="S" last="Padma">S. Padma</name></author><author><name sortKey="Abhilash, G" sort="Abhilash, G" uniqKey="Abhilash G" first="G" last="Abhilash">G. Abhilash</name></author><author><name sortKey="Ramesh, C" sort="Ramesh, C" uniqKey="Ramesh C" first="C" last="Ramesh">C. Ramesh</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Brugia malayi (isolation & purification)</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>India (epidemiology)</term><term>Lymph Nodes (diagnostic imaging)</term><term>Male</term><term>Radionuclide Imaging</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Animaux</term><term>Brugia malayi (isolement et purification)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (parasitologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Inde (épidémiologie)</term><term>Mâle</term><term>Noeuds lymphatiques (imagerie diagnostique)</term><term>Scintigraphie</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Radionuclide Imaging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Scintigraphie</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As the more obvious clinical manifestations of the disease are very uncommon in children, lymphatic filariasis has been considered to be primarily a disease of adults. In many recent reports, however, there is evidence indicating not only that filarial infection is commonly acquired in childhood but also that many infected children already have irreversible damage to their lymphatics. The preliminary results of a cross-sectional study on the patterns of Brugia-attributable pathology in 7934 children (aged 3-15 years) who live in an area of India with endemic B. malayi infection confirm these trends. The children were screened for microfilaraemia, evidence of filarial disease, and the presence of antifilarial IgG(4) antibodies. One hundred children who were microfilaraemic but asymptomatic (32), with filarial disease or an history of such disease or microfilaraemia (29) or amicrofilaraemic and asymptomatic but seropositive for antifilarial IgG(4) (39) were investigated further. They were given detailed clinical examinations, their levels of microfilaraemia were evaluated (by counting microfilariae filtered out of blood samples), their lymphatics were explored by Doppler sonography, and their limbs were checked by lymphoscintigraphy. The 'filarial dance sign', which indicates the presence of live adult worms, was detected by sonography in 14 children (apparently the first time this sign has been observed in brugian filariasis). Lymphoscintigraphy revealed dilated lymphatic channels in the limbs of 80 of the children. At the end of the study, each of the 100 hospitalized children was treated with a single combined dose of diethylcarbamazine and albendazole; the aim is to follow-up the treated children every 6 months for 3 years. Even these preliminary results have important implications for filariasis-control programmes and emphasise the need for disability-alleviation efforts among children as well as adults.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Abhilash, G" sort="Abhilash, G" uniqKey="Abhilash G" first="G" last="Abhilash">G. Abhilash</name><name sortKey="Dhananjayan, G" sort="Dhananjayan, G" uniqKey="Dhananjayan G" first="G" last="Dhananjayan">G. Dhananjayan</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name><name sortKey="Padma, S" sort="Padma, S" uniqKey="Padma S" first="S" last="Padma">S. Padma</name><name sortKey="Rahmah, N" sort="Rahmah, N" uniqKey="Rahmah N" first="N" last="Rahmah">N. Rahmah</name><name sortKey="Ramesh, C" sort="Ramesh, C" uniqKey="Ramesh C" first="C" last="Ramesh">C. Ramesh</name><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></noCountry><country name="Inde"><noRegion><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007147 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007147 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:17362595
|texte= Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17362595" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |